Selected Publications

Li W, Xiong Y, Shang C, Twu K, Hang C, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP. "Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development." PNAS 2013 Jan. 29; 110(5):1738-43.

Wu B, Zhang Z, Lui W, Chen X, Wang Y, Chamberlain A, Moreno-Rodriquez RA, Markwald RR, O’Rourke RP, Sharp DJ, Zheng D, Lenz J, Baldwin HS, Chang CP, Zhou B.. "Endocardial Cells Form Coronary Arteries by Angiogenesis through Myocardial to Endocardial VEGF Signaling." Cell 2012 Nov. 21; 1083-1096.

Chang CP, Bruneau B. "Epigenetics and cardiovascular development." Annu Rev Physiol. 2012 Feb 15.; 74: 13.1-13.28.

Han P, Hang CT, Yang J, Chang CP. "Chromatin remodeling in cardiovascular development and physiology." Circulation Research. 2011 Feb 4; 108: 378-96.(PDF)

Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP. "Chromatin regulation by Brg1 underlies heart muscle development and disease." Nature. 2010; 466(7302):62-67.(PDF)

Bajpai R, Chen DA, Rada-Iglesias A, Zhang J, Xiong Y, Helms J, Chang CP, Zhao Y, Swigut T, Wysocka J. "CHD7 cooperates with PBAF to control multipotent neural crest formation." Nature. 2010; 463 (7283):958-62.

Zeini M, Hang CT, Lehrer-Graiwer J, Dao T, Zhou B, Chang CP. "Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling." Development. 2009 Aug 26.(PDF)

Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR. "Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation." Science. 2009; 323 (5914):651-4

Chang CP, Stankunas K, Shang C, Kao, Twu KY, and Cleary ML. "Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract." Development. 2008 Nov;135(21):3577-86. (PDF)

Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP. "Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis." Dev Cell. 2008 Feb; 14(2): 298-311. PMID: 18267097 (PDF)

Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP. "Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development." J Biol Chem 2007; 282: 42: 30673-9 (PDF)

Jia Q, McDill BW, Li SZ, Deng C, Chang CP, Chen F "Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects." Dev Biol 2007; 311: 1: 172-84 (PDF)

Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. "NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21." Nature 2006; 441(7093):595-600

Sheikh AY, Lin SA, Cao F, Cao Y, van der Bogt KE, Chu P, Chang CP, Contag CH, Robbins RC, Wu JC "Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium." Stem Cells 2007; 25: 10: 2677-84 (PDF)

Arron J, Winslow M, Polleri A, Chang CP, Wu H, Gao X, Neilson J, Chen L, Heit J, Kim S, Yamasaki N, Miyakawa T, Francke U, Graef I, Crabtree G. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006 Jun 1;441(7093):595-600 (PDF)

Kofidis T, de Bruin JL, Hoyt G, Lebl DR, Tanaka M, Yamane T, Chang CP, Robbins RC. Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle. J Thorac Cardiovasc Surg. 2004 Oct; 128(4), 571-8 (PDF)

Kofidis T, de Bruin JL, Hoyt G, Ho Y, Tanaka M, Yamane T, Lebl DR, Swijnenburg RJ, Chang CP, Quertermous T, Robbins RC "Myocardial restoration with embryonic stem cell bioartificial tissue transplantation." J Heart Lung Transplant 2005; 24: 6: 737-44. (PDF)

Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F. Calcineurin is required in the urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 2004 Apr;113(7):1051-8. Editorial commentary: Mendelsohn C. Functional obstruction: the renal pelvis rules. J Clin Invest 2004 Apr;113(7): 957-959 (PDF)

Chang CP, Chen L, Crabtree GR. Sonographic staging of the developmental status of mouse embryos in utero. Genesis: the Journal of Genetics and Development 2003;36(1):7-11 (PDF)

Rugolotto M, Chang CP, Hu BS, Schnittger I, Liang D. Clinical use of cardiac ultrasound performed with a hand-carried device in patients admitted for acute cardiac care. Am J Cardiol 2002; 90(9):1040-1042

Pelletier M, Chang CP, Vagelos R and Robbins R. Alternative approach for use of a left ventricular assist device with a thrombosed prosthetic valve. Journal of Heart and Lung Transplantation, 2002; 21(3):402-404 (PDF)

Piper DE, Batchelor A, Chang CP, Cleary ML, and Wolberger, C. Crystal structure of a HoxB1-Pbx1a heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation." Cell, Vol. 96, 587-597, Feb. 1999 (PDF)

Chang CP, Jacobs Y, Nakamura T, Jenkins NA, Copeland NG, Cleary ML.  Meis proteins are major  in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.  Molecular and Cellular Biology, Oct. 1997, Vol. 17, No. 10, 5679-5687. (PDF)

Chang CP, De Vivo I, Cleary ML.  The Hox cooperativity motif of chimeric oncoprotein E2a-Pbx1 is   necessary and sufficient for oncogenesis.  Molecular and Cellular Biology, Jan.1997, Vol.17, No. 1, 81-88. (PDF)

Chang CP, Luciano Brocchieri, Shen WF, Largman C, Cleary ML.  Pbx modulation of Hox homeodomain N- terminal arms establishes a gradient of DNA-binding specificities across the Hox locus.  Molecular and Cellular Biology, April 1996, Vol. 16, No 4, 1734-1745 (PDF)

Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes and Development, 1995 March 15, 9(6):663-74 (PDF)